摘要
探讨了环糊精对美西律对映体手性识别的机理。对毛细管电泳手性分离选择系数α 值和环糊精包结常数的计算方法做了修正，计算了甲基化β环糊精与对映体形成包结络合 物的稳定常数和手性分离过程中的热力学参数，并对由该方法计算的结果进行了分析。结果 表明，环糊精对美西律对映体包结常数的大小顺序与它们的手性分离选择性相反；但是，手性 分离过程中的焓变（Δ（ΔＨ））和熵变（Δ（ΔＳ））越大，手性分离选择性也越大。根据计算结果， ＴＭ－β－ＣＤ与美西律对映体之间的手性识别相互作用要强于ＤＭ－β－ＣＤ。
The chiral recognition of cyclodextrins (CDs) for mexiletine enantiomers was in- vestigated by capillary electrophoresis (CE). The method for determination of the chiral sep- aration factor βin capillary electrophoresis has been modified due to the reason that βcan not be simply obtained by the value of t2/t1 when the chiral selector migrates with a certain veloc- ity in CE. The equilibrium constants of inclusion complex of CDs with enantiomers and the thermodynamic parameters were determined and analyzed. It was found that the chiral selec- tivity values have the same magnitude sequence as Δ(ΔH) and Δ(ΔS) and opposite order a- gainst the equilibrium constants of inclusion complexes when DM-β-CD and TM-β-CD were used as chiral selector respectively. Because the thermodynamic parameter for chiral recogni- tion of TM-β-CD is larger than that of DM-β-CD, it was considered that interactions of TM- β-CD with mexiletine enantiomers for chiral recognition should be stronger than that of DM- β-CD.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1997年第10期1117-1122,共6页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金
中国科学院兰州化学物理研究所所长基金
关键词
毛细管电泳
手性分离
盐酸美西律
对映体
拆分
Capillary electrophoresis, chiral separation mechanism, mexiletine chloride
