摘要
目的:探讨老年急性冠脉综合征患者血清瘦素、肿瘤坏死因子-α水平的变化及临床意义。方法:测定老年急性心肌梗死(n=30,AMI组)和不稳定型心绞痛(n=30,UA组)患者血清瘦素和肿瘤坏死因子-α水平,另设30例健康体检者作为对照组,分析血清瘦素与病情严重程度的关系。结果:AMI组、UA组患者血清瘦素和肿瘤坏死因子-α水平较正常对照组显著升高(P<0.01);AMI组血清瘦素和肿瘤坏死因子-α浓度明显高于UA组(P<0.05)。AMI患者瘦素水平与TNF-α呈正相关。结论:瘦素可能参与了急性冠脉综合征心肌损伤过程,血清瘦素是老年急性冠脉综合征患者重要的危险因素及预测因子,而且与病情严重程度呈正相关。
Objective To investigate the changes of serum leptin and tumor necrosis factor-α levels and their clinical significance in elderly patients with acute coronary syndrome. Methods Serum leptin and tumor necrosis factor-α levels were detected in patients with acute myocardial infarction（AMI group, n=30） and unstable angina （UA group, n=30）. Another 30 healthy subjects were enrolled as control group. The relationship between serum leptin and tumor necrosis factor-α levels and severity of acute coronary syndrome were analyzed. Results As compared with control group, there was a significant increase in serum leptin and tumor necrosis factor-α levels in AMI and UA group （P〈0. 01）. The serum leptin and tumor necrosis faetor-α levels in AMI group were significantly higher than those in UA group （P〈0.01）. The serum leptin levels in acute coronary syndrome patients were positively correlated with tumor necrosis factor-α. Conclusion Higher level of leptin in serum may be involved in myocardial deteriorating process. The serum leptin level is an important risk and predictive factor for elderly patients with acute coronary syndrome, which is positively correlated with the severity of acute coronary syndrome.
出处
《中华实用诊断与治疗杂志》
2008年第10期748-749,753,共3页
Journal of Chinese Practical Diagnosis and Therapy
