摘要
目的探讨血浆脂肪因子Apelin水平与2型糖尿病合并冠心病风险的关系。方法 2型糖尿病患者138例,依据是否合并冠心病分为合并冠心病组59例与未合并冠心病组79例,比较2组血浆Apelin水平,采用多因素Logistic回归分析评价血浆Apelin水平与冠心病发生的相关性。结果合并冠心病组血浆Apelin水平为(2.38±0.63)ng/mL,明显低于未合并冠心病组(4.82±1.06)ng/mL(P<0.01);多因素Logistic回归分析结果显示,低血浆Apelin水平是2型糖尿病患者罹患冠心病的独立危险因子(OR=0.694,95%CI:0.428～0.873,P<0.01)。结论检测血浆Apelin水平可用于评估2型糖尿病患者罹患冠心病的风险。
Objective To investigate the correlation of plasma apelin level with coronary heart disease （CHD） in patients with type 2 diabetes mellitus （T2DM）. Methods A total of 138 patients with type 2 diabetes mellitus were divided into two groups, CHD group （patients complicated with CHD, n= 59） and control group （patients not complicated with CHD, n 79）. The apelin level was compared between two groups and multivariate logistic analysis method was used to investigate the correlation between plasma Apelin level and CHD. Results The apelin level was significantly lower in CHD group than that in control group （（2.38±0.63） ng/mL vs （4.82±1.06） ng/mL, P〈0.01）. Multivariate logistic regression revealed that lower apelin level was an independent risk factor for CHD in patients with T2DM （OR： 0. 694, 95%CI： 0. 428 to 0. 873; P〈0.01）. Conclusion The detection of plasma apelin level might be a promising method for predicting the risk of CHD in patients with T2DM.
出处
《中华实用诊断与治疗杂志》
2013年第1期36-37,共2页
Journal of Chinese Practical Diagnosis and Therapy
关键词
2型糖尿病
冠心病
脂肪因子
APELIN
Type 2 diabetes mellitus
coronary heart disease
adipokine
apelin
