摘要
目的探讨2型糖尿病患者血清瘦素(Leptin)和生长激素释放肽(Ghrelin)与胰岛素抵抗的相关性。方法随机选定62例2型糖尿病患者和48例正常对照人群,并根据BMI将糖尿病人群分为肥胖糖尿病组和非肥胖糖尿病组,均测定身高、体重、空腹血糖(FPG)、空腹胰岛素(FINS)、Leptin、Ghrelin和血脂,计算胰岛素抵抗指数(HOMA-IR),分析Leptin、Ghrelin与HOMA-IR的相关性。结果与对照组比较,糖尿病组Ghrelin水平明显下降(P<0.001),而Leptin水平无显著性差异(P>0.05);与非肥胖糖尿病组比较,肥胖糖尿病组Leptin水平明显增高(P<0.001),而Ghrelin无显著性差异(P>0.05)。糖尿病患者中HOMA-IR与Ghrelin呈负相关(r=-0.372,P=0.043);与Leptin呈正相关(r=0.389,P=0.034),Ghrelin与Leptin呈负相关(r=-0.362,P=0.049)。结论2型糖尿病患者血清Leptin和Ghrelin与胰岛素抵抗密切相关。
Objective To investigate the association between serum Lepfin、Ghrelin and insulin resistance in type 2 diabetes. Methods To select 48 participants in the control group and 62 type 2 diabetes patients which were divided into two groups according to BMI：diabetic obese group and diabic norreal BMI group, their weight and height were measured. Fasting plasma glucose（FPG）, fasting insulin （FINS） ,Leptin, Ghrelin and blood lipids were also measured. Then to compute HOMA index（HOMA-IR） and to analyse the relation between serum Leptin、Ghrelin and HOMA-IR. Results In the diabetes, the plasma Ghrelin was significantly lower than that of the control（ P 〈 0. 001 ）, and it was negatively correlated with HOMA-IR （ r = - 0. 372, P = 0. 043 ） ; Compared with diabetic normal BMI group, the plasmas Leptin concentration of the diabetic obese group was significantly higher（ P 〈 0. 001 ） ,Whereas the serum Ghrelin concentration had no significant difference（ P 〉 0.05 ）. In type 2 diabetes serum Leptin concentration had no significant difference with normal control（ P 〉 0.05 ）, but it was positively correlated with HOMA-IR（ r = 0.389, P = 0. 034 ） ; Serum Leptin was also negatively correlated with Ghrelin. Conclusion Serum Leptin and Ghrelin level are associated with insulin resistance in patients with type 2 diabetes.
出处
《临床内科杂志》
CAS
2007年第2期112-114,共3页
Journal of Clinical Internal Medicine
基金
甘肃省中青年科技基金(编号:YS001-A23-019)
