摘要
为探讨白细胞介素－５（ＩＬ－５）在支气管哮喘患者气道炎症过程中的作用，随机选择８例哮喘患者雾化吸入人重组ＩＬ－５，并分别于吸入前、吸入后２ｈ、２４ｈ和４８ｈ以放射免疫法测定痰液中嗜酸阳离子蛋白（ＥＣＰ）水平。结果发现吸入ＩＬ－５后ＥＣＰ水平均随时间而明显升高，至２４ｈ达最高值，４８ｈ后仍维持在较高水平。这些资料提示ＩＬ－５不仅可以直接趋化嗜酸性粒细胞浸润到哮喘患者的呼吸道，而且还能招致其活化从而参与哮喘的发病过程。
In order to investigate the role of interleukin(IL) 5 in the eosinophilic inflammation of asthmatic airways,eight nonsmokin patients with allergic asthma were treated with recombinant human IL 5 by nebulization The levels of the eosinophil cationic protein(ECP) in the sputum were determined before,and at 2,24,48 h after inhalation Results:Comparing with the pre inhalation baseline value(279 5±45 5 μg/L),inhalation of IL 5 led to a gradual increase of ECPlevels,reaching a maximum value at 24 h(773 5±97 9 μg/L,P<0 01),which lasted at least 48 h(738 5±89 5 μg/L,P<0 01) The results indicate that IL 5 not only can induce eosinophilic infiltration of the asthmatic airways,but also can activate the eosinophils
出处
《广西医科大学学报》
CAS
1997年第3期1-4,共4页
Journal of Guangxi Medical University
基金
区教委科研资助
