摘要
目的：探讨白细胞介素－５（ＩＬ－５）在支气管哮喘发病机理中的作用。方法：选择８例哮喘患者雾化吸入人重组ＩＬ－５，并分别于吸入前、吸入后２、２４和４８ｈ采集静脉血分离血清，并以放射免疫法测定血清中嗜酸阳离子蛋白（ＥＣＰ）水平。结果：与吸入ＩＬ－５前基础值［（６．３±１．１）μｇ／Ｌ］相比较，吸入ＩＬ－５后ＥＣＰ水平均随时间而明显升高，至２４ｈ达最高值（１７．６±２．８）μｇ／Ｌ，（Ｐ＜０．０１），４８ｈ后仍维持在较高水平［（１８．１±２．９）μｇ／Ｌ，Ｐ＜０．０１］。结论：吸入ＩＬ－５可以激活循环中嗜酸性粒细胞。
Objective:The role of interleukin(IL) 5 in the pathogenesis of bronchial asthma was investigated.Methods:Eight nonsmoking patients with allergic asthma were administered recombinant human IL 5 by nebulization.Sera were collected,and concentrations of eosinophil cationic protein(ECP)in circulation were determied before,and at 2,24,48 h after inhalation,respectively.Results:It was demonstrated that compared with baseline value[(6 3±1 1)μg/L],inhalation of IL 5 leads to increase of ECP levels with time,reaching a significant higher point at 24 h[(17 6±2 8)μg/L,P<0 01]and this elevated ECP levels lasted at least 48 h [(18 1±2 9)μg/L,P<0 01].Conclusions:Our data provided direct evidence that IL 5 is capable of activating eosinophils in circulation which are involved in the pathogensis of asthma.
出处
《广西医科大学学报》
CAS
1998年第2期26-28,共3页
Journal of Guangxi Medical University
