摘要
肝型脂肪酸结合蛋白(L-FABP)是脂肪酸结合蛋白(FABPs)家族成员之一,与其他成员结构和功能方面有相同之处又有区别.L-FABP主要表达于肝脏组织和小肠,介导脂肪酸及多种疏水基团转运,涉及多种疾病的发病机制.多年来其转运机制备受关注,研究方法从体外到体内,从细胞分子水平到基因沉默动物水平.虽然L-FABP的转运机制研究越来越深入,但是仍需要进一步加强基础研究,揭示其调控脂类转运的机制.本文主要对L-FABP的特性、结构及体内研究现状作一综述.
Liver-type fatty acid-binding protein （L-FABP）, a member of the genetically related cytosolic fatty acid binding protein （FABP） family, has both simi-lar and different function and conformation com-pared with other family members. L-FABP, which is mainly found in liver and small intestine, par-ticipates in transporting fatty acids and combining a variety of hydrophobic group and is associated with many diseases. In recent years, the transfer mechanism of L-FABP was attracting great atten-tion, and the research methods were developed from in vitro to in vivo, and from cell molecular level to gene ablation animals. Although a part of the mechanism has been revealed, the research should be continued to demonstrate it in deepth and resolve some new questions. This article aims to review the characteristics, conformation and in vivo study status of L-FABP.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第27期3065-3069,共5页
World Chinese Journal of Digestology
基金
黑龙江省自然科学基金资助项目
No.D2007-59
黑龙江省教育厅科学技术研究资助项目
No.11533071~~
关键词
肝性脂肪酸结合蛋白
脂肪酸
转运
转录调控
Liver-type fatty acid-binding protein
Fatty acid
Transport
Transcription regulation
