摘要
目的探讨非酒精性脂肪肝(NAFLD)患者血清肝型脂肪酸结合蛋白(L-FABP)变化及其临床意义。方法用ELISA法测定90例NAFLD患者血清L-FABP的变化,同时计算体重指数(BMI),腰臀比(WHR);肝功能(丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转移酶(γ-GT));血脂(总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C));空腹血浆葡萄糖(FBG)和胰岛素抵抗指数(HOMA-IR)。并与健康对照组(n=80)进行比较。结果 NAFLD组的血清L-FABP明显高于健康对照组(P<0.01)且与NAFLD严重程度有关;NAFLD组BMI、WHR、FBG、HOMA-IR、AST、γ-GT、TG、LDL-C水平明显高于健康对照组(P<0.05),血清HDLC水平明显低于健康对照组(P<0.05);L-FABP与BMI(r=0.7365)、WHR(r=0.6713)、FBG(r=0.6368)、HOMA-IR(r=0.6539)、AST(r=0.6640)、γ-GT(r=0.6768)、TG(r=0.7012)、LDL-C(r=0.6034)呈正相关(P<0.01),与HDL-C(r=-0.6839)呈负相关(P<0.01)。结论 L-FABP可能参与NAFLD发病机制的发生与发展过程,随着对L-FABP研究和认识的深入,血清L-FABP可能成为NAFLD的临床病情观察的新指标,并为药物靶向治疗提供新思路。
Objective To investigate the change of liver fatty acid binding protein（ L - FABP） in serum of human nonalcoholic fatty liver disease（ NAFLD）, and to explore the clinical significance. Methods Totally 90 NAFLD patients were employed as reach group and another 80 health peoples were enrolled as control group. Indexes as L - FABP, body weight index （ BMI ） , waist - hip ratio （ WHR ） , hepatic alanine aminotransferase （ALT） , hepatic aspartate aminotransferase（ AST）, hepatic γ- glutamyltransferase（ γ - GT）, TC, TG, LDL - C, HDL - C, FBG, HOMA - IR were detected and compared. Results Compared with control group, the level of serum L - FABP in the NAFLD group was obviously increased （ P 〈 0. 01 ）, and correlated with its severity. Compared with normal group, the level of BMI, WHR, FBG, HOMA - IR, AST, γ - GT, TG, LDL - C of NAFLD group were obviously increased （ P 〈 0. 05 ）, but the level of serum HDL - C was obviously decreased （ P 〈 0. 05 ）. L - FABP positively correlated with levels of BMI（ r=0. 7365 ）, WHR（ r = 0. 6713 ）, FBG （ r = 0. 6368 ）, HOMA - IR（r =0. 6539）, AST（r =0. 6640）, γ - GT（r =0. 6768） ,TG（r =0. 7012） ,LDL - C（r =0. 6034） （P 〈 0. 01 ）, but had a negative linear correlation with HDL - C （ r = - O. 6839 ）, （ P 〈 0. 01 ）. Conclusions L - FABP may take part in the occurrence and development process of NAFLD pathogenesis. With the in - depth study and understanding of L - FABP, serum L - FABP may be a new indicator of the clinical observation of disease, and could provide new ideas for targeted therapy of drugs.
出处
《齐齐哈尔医学院学报》
2014年第11期1566-1568,共3页
Journal of Qiqihar Medical University
基金
2014年获珠海市科技局科研立项
