摘要
采用胰腺被膜下注射5％牛磺胆酸钠复制急性坏死性胰腺炎合并肺损伤模型。用放射免疫方法测定血浆和肺组织的TXB2（ThromboxaneB2）、6-Keto－PGF1α（6-Ke－to－prostagland1α）水平。结果显示：随着肺损伤程度加重，血浆和肺组织的TXB2（血栓素B2）值明显升高，6-Keto－PGF1α（6-酮-前列环素1α）变化不明显，TXB2／6-Keto－PGF1α比值显著升高，表明TXB2／6-Keto－PGF1α平衡的改变可能是急性坏死性胰腺炎并发肺损伤的主要作用机制之一。
A model of acute necrotizing pancre-atitis in rats was produced by injecting 5% sodium taurocholate under the pancreatic coating. The level of thromboxane B2 and 6-keto-prostaglandin F1α in plasma and lung tissue was observed by radioim-munoassay. The results showed that with the deep-ening of lung injury, the level of plasma and lung tissue TXB2 and TXB2/6-keto-PGF1α ratio Were ele-vated Drogressivelv, but level of 6-keto-PGF1αshowed no change. The changes of TXB2/6-keto-PGF1α balance may be one of major mechanisms re-sponsible for pulmonary injury caused by acute necrotizing pancreatitis.
出处
《西安医科大学学报》
CSCD
1997年第3期354-356,360,共4页
Journal of Xi'an Medical University(Chinese)
关键词
血栓素B2
肺损伤
急性
坏死性
胰腺炎
并发证
prostaglandin
thromboxane B_2
lung injury
acute necrotizing pancreatitis
