摘要
目的:了解我院药品不良反应(ADR)的发生特点。方法:对我院2001年1月～2007年8月收集到的1197例ADR报告,按患者性别、年龄、用药情况、涉及器官或系统以及临床表现等进行统计、分析。结果:1197例ADR中,41～60a年龄段患者ADR发生率较高(33.0%),男性略高于女性;静脉给药方式是导致ADR的重要途径(59.9%);ADR发生率最多的为抗感染药(53.5%),其中绝大多数是由喹诺酮类和头孢菌素类引发,其次为中药制剂;临床表现以皮肤及其附件损害最常见(49.2%),其次为消化系统和循环系统损害。结论:应加强抗感染药合理使用与管理,以减少和避免ADR发生;同时开展全方位的ADR监测工作,逐步提高ADR报告质量。
OBJECTIVE： To analysis the characteristics of the adverse drug reaction （ADR） occurred in our hospital. METHODS： 1 197 ADR cases collected from Jan. 2001 to Aug. 2007 in our hospital were analyzed statistically in respect of patient＇ s age and sex, drug utilization, drug categories, organs and systems involved and clinical manifestations of ADR etc. RESULTS： In the total 1 197 ADR cases, 33.0% occurred in patients aged from 41 to 60, with males showing slightly higher percentage than females, 59.9% were induced through intravenous way, 53.5% were induced by antimicrobial drugs, of which, quinoloned and cephalosprins took the lead, followed by Chinese drugs preparations. The most common manifestation of the ADR was damage of skin and its appendants （49.2%）, followed by lesions of alimentary system and circulation system. CONCLUSION： Anti- infective drugs should he used rationally to reduce or avoid the occurrence of ADR. Meanwhile, ADR monitoring should be strengthened to improve the quality of ADR reports.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第29期2294-2296,共3页
China Pharmacy
