摘要
作者给小鼠肌肉注射马桑内酯2.5mg/kg,引起重型癫痫发作,测定小鼠皮层和海马的环磷酸腺苷(cAMP)水平。结果表明:在癫痫发作之前和轻型发作时,小鼠皮层和海马的cAMP含量无明显改变;重型发作和发作结束后,小鼠皮层和海马的cAMP水平显著增加。此结果提示癫痫发作时脑内cAMP水平增加,很可能是发作的结果而不是引起发作的原因。
To study the relationship betweencAMP and epilepsy, we investigated theeffects of coriaria lactone (CL) on thelevels of cAMP in cerebral cortex andhippocampus. Fifty normal WC_1 micewere divided into 5 groups. All groupswere injected with CL (2. 5mg/kg, i. m. ),except tbe control group which was injectedwith NS. The concentrations of cAMPwere measured after the animals had beenimmersed in liquid nitrogen to die atdifferent phases of seizure developmentinduced by CL (before seizures, in mildSeizures, during severe seizures, and aftersevere seizures). The results indicatedthat the levels of cAMP in both cerebralcortex and hippocampus were significantlyincreased (1. 73-fold and 1. 33-fold) in severeseizure, and they continuously increa-sed(1.85-fold and 1.45-fold) after severeseizures. On the other hand,no changesof cAMP were observed in mild seizuresand before seizures. These data suggestedthat accumulation of cAMP is probablythe result of seizure activity rather thanthe cause of seizure.
出处
《华西医科大学学报》
CAS
CSCD
1990年第4期387-389,共3页
Journal of West China University of Medical Sciences
基金
国家自然科学基金
