摘要
作者制成犬急性出血坏死性胰腺炎(AHNP)模型,并对其血液流变学变化进行了系统观察。发现在犬AHNP早期,其血液流变学即发生显著异常,并随病程进展而加重,导致胰腺微循环障碍,使胰腺炎病变不断恶化;使用药物改善血液流变学异常后,胰腺炎病变即有明显好转。表明血液流变学异常在AHNP病变恶化过程中占有重要地位。并提示改善血液流变学的药物对AHNP的治疗是有益的。
The hemorheologic alterations werestudied in experimental acute hemorrhagicnecrotizing pancreatitis (AHNP) which wasinduced by injection of 5% sodium tauro-cholate into the main pancreatic duct. Theresults showed that during the early stageof AHNP, all of hemorheologic parameterswere significantly elevated, and continuallyincreased at the rest intervals. The authorssuggested that the blood viscosity and hem-atocrit increase, red blood cells tend toaggregate, and erythrocyte deformation de-crease are the causation of pancreatic mi-crocirculatory disturbances and promotingpancreatic progressive necrosis. After usinglow molecular dextran and Salvia miltiorr-hizae, the hemorheologic alterations inAHNP were recovered, and the histologicobservation improved. Our dada indicatethe hemorheologic disturbances is one ofthe key factors in the pathogenesis ofAHNP.
出处
《华西医科大学学报》
CAS
CSCD
1990年第1期25-29,共5页
Journal of West China University of Medical Sciences
基金
四川省科委资助课题
关键词
胰腺炎
血液流变学
AHNP
病理
Acute hemorrhagic necrotizing pancreatitis
Hemorheology
Pancreatic microcirculation
Low molecular dextran
Salvia miltiorrhizae
Dog
