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凝血酶在脑出血后脑水肿形成中的作用 被引量：2

The Role of Thrombin in Edema Formation After Intracerebral Hemorrhage
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摘要 文章阐述了凝血酶和凝血酶受体的分子结构和生物学特性，重点讨论了凝血酶通过促发细胞炎症反应、细胞凋亡以及损害血脑屏障导致脑出血后脑水肿形成的机制。 The article describes the molecular structure and biological characteristics of thrombin and thrombin receptor. It manly discusses thrombin caused the mechamisms of cerebral edema formation after intracerebral hemorrhage by promoting cell inflarrrnatory reaction, neuron apoptosis and injurying blood-brain barrier.
作者 李强 李威 丁素菊
机构地区 上海交通大学附属第九人民医院神经内科 第二军医大学长海医院神经内科
出处 《国际脑血管病杂志》 2008年第8期592-594,共3页 International Journal of Cerebrovascular Diseases
关键词 凝血酶 脑出血 脑水肿 细胞凋亡 血脑屏障 炎症 thrombin intracerebral haemorrhage brain edema apoptosis blood-brain barrier inflammation
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献15

  • 1Di Cera E, Cantwell AM. Determinants of thrombin specificity. Ann N Y Acad Sci, 2001,936:133 - 146.
  • 2Royle NJ, Irwin DM, Koschinsky ML, el al. Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively. Somat Cell Mol Genet, 1987, 13:285 -292.
  • 3Cuan J, Sun S, Cao X, et al. Experimental study on the PAR-1 expression around hemotoma following intracerebral hemorrhage in rats. J Huazhong Univ Sci Technolog Med Sci, 2004, 24:266 -268.
  • 4姜亚军,常诚,张琳,吴明华,符为民,吴灏昕.脑出血后脑组织内凝血酶受体1(PAR1)的表达及其病理意义[J].中风与神经疾病杂志,2004,21(2):100-103. 被引量：31
  • 5Xi G, Hua Y, Keep RF, et al. Induction of colligin may attenuate brain edema following intracerebral hemorrhage. Acta Neurochir Suppl, 2000, 76:501 -505.
  • 6Donovan FM, Cunningham DD. Signaling pathways involved in thrombininduced cell protection. J Biol Chem, 1998,273:12746 - 12752.
  • 7Striggow F,Riek M, Breder J, et al. The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc Natl Acad Sci USA, 2000, 97:2264 -2269.
  • 8Masada T, Hua Y, Xi G, et al. Attenuation of intracerebral hemorrhage and thrombin-induced brain edema by overexpression of interleukin-1 receptor antagonist. J Neurosurg , 2001,95:680 -686.
  • 9Ryu J, Pyo H, Jou l, et al. Thrombin induces NO release from cultured rat microgtia via protein kinase C, mitogen-activated protein kinase, and NF-κB. J Biol Chem, 2000, 275:29955 -29959.
  • 10Rahman A, Anwar KN, True AL, et al. Thrombin-induced p65 homodimer binding to downstream NF-κB site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion. J Immunol, 1999, 162:5466 -5476.

二级参考文献8

  • 1Lee KR,Colon GP,Betz AL,et al.Edema from intracerebral hemorrhage:the role of thrombin[J].J Neurosurg,1996,84:91-96.
  • 2Vu TK,Hung DT,Wheaton VI,et al.Molecular cloning of a functional thrombin receptor reveals a novel protealytic mechanism of receptor activation[J].Cell,1991,64:1057-1068.
  • 3Weinatein JR,Gold SJ,Cunningham DD,et al.Cellular location of thrombin receptor mRNA in rat brains:expression by mesescephalic dopaminenergic neurons and codistribution with prothrombin mRNA[J].J Neurosci,1995,15:2906-2919.
  • 4Nath FP,Jenkins A,Medelow A,et al.Early hemodynamic changes in experimental intracerebral hemorrhage [J].J Neurosurg,1986,65:697-703.
  • 5Yajun Jiang,Jiming Wu,Ya Hua,et al.Thrombin-receptor activation and thrombin-induced brain edema [J].J Cereb Blood Flow and Metab,2002,22:404-410.
  • 6Donovan FM,Pike CJ,Cotman CW,et al.Thrombin induces apoptosis in cultured neurons and astrocytes via a pathway requiring tyrosine kinase and RhoA activities[J].J Neurosci,1997,17(14):5316-5326.
  • 7Gingrich MB,Junge CE,Lynboslavsky P,et al.Potentiation of NMDA receptor by the serine protease thrombin[J].J Neurosci,2000,20(12):4582-4595.
  • 8Moller T,Hanisch UK,Tansom BR.Thrombin-induced activation of cultured rodent microglia[J].J Neurochem,2000,75:1539-1547.

共引文献30

同被引文献20

二级引证文献22

国际脑血管病杂志
2008年 第8期

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