摘要
目的:探讨老年急性冠脉综合征患者血小板P选择素和血小板参数的变化及相关关系。方法:60例老年急性冠脉综合征患者,其中急性心肌梗死30例,不稳定型心绞痛30例,稳定性心绞痛30例,另设对照组30例。采用全血法流式细胞术及血球计数仪对各组血小板P选择素、血小板参数进行测定。结果:老年急性冠脉综合征患者P选择素、血小板平均体积、血小板压积和血小板体积分布宽度明显高于对照组(P<0.05),血小板计数低于对照组(P<0.05)。急性冠脉综合征患者P选择素浓度与血小板平均体积、血小板体积分布宽度呈正相关(r分别为0.24、0.48,P<0.05),与血小板计数呈负相关(r=-0.34,P<0.05)。结论:P选择素参与了急性冠脉综合征并发挥重要作用,其水平变化与血小板计数、血小板体积分布宽度和血小板平均体积有关。
Objective To investigate the platelet P-selection level and platelet parameters in senile patients with acute coronary syndrome. Methods Sixty patients with acute coronary syndrome （30 patients with acute myocardial infarction and 30 patients with unstable angina） were enrolled. The levels of activated P-selection on platelets were analyzed with flow cytometry and platelet parameters were collected. Results The levels of P-selection, mean platelet volume, plateletocrit and platelet distribution width in senile patients with acute coronary syndrome were higher than those in control group significantly（P〈0. 05）. The platelet count in senile patients with acute coronary syndrome was lower than that in control group significantly（P〈 0. 05）. The level of P-selection was positively correlated with mean platelet volume and platelet distribution width, and negatively correlated with platelet count. Conclusion The P-selection plays a crucial role in the development of acute coronary syndrome and the P-selection level is related to mean platelet volume, platelet distribution width and platelet count.
出处
《中华实用诊断与治疗杂志》
2008年第9期667-668,671,共3页
Journal of Chinese Practical Diagnosis and Therapy
