摘要
目的通过对溃疡性结肠炎大鼠(UC)的血清TLC亚群的检测和IgG、溶菌酶(LZM)含量的测定,探讨苏木对UC大鼠免疫功能的调节作用。方法将Wistar大鼠随机分成6组,除正常对照组外,其余各组大鼠用免疫学方法制作实验UC模型。正常对照组和模型对照组每天灌服0.9%NaCl溶液2次,每次2 mL,药物组每天灌服苏木水提物药品液2次,每次2 mL,3周后处死后,检测各免疫指标。结果苏木治疗组的CD4+/CD8+明显低于模型对照组,IgG的含量与模型组比较,12.5 g/kg、25.0 g/kg剂量组明显降低血清IgG水平,LSZ的含量也明显低于模型组,差异有显著性。治疗组胸腺指数和脾指数与模型组比较,差异无显著性。结论苏木对UC大鼠的免疫功能有一定的调节作用。
Objective To explore the regulation effect of haematoxylin on immunogenic reaction of rats suffered from UC by serum TLC subgroup, IgG and lysozyrne level examination. Methods The adults Wistar rats were randomly divided into six groups, the models of UC （ except the normal group） have been made by immune methods. Normal group and UC group were administered 0.9% NaC1 solution 2 mL（2 times a day）. AELS groups were administered AELS solution 2 mL（2 times a day）. These rats were killed after three weeks. All index were examined. Results The CD4^＋ 8 ＋ levels in haematoxylin treatment groups was significantly lower than that of models controls. The IgG levels in haematoxylin treatment groups was significantly lower than that of the models group. The level of LSZ was significantly lower than level of model group. There was not significant relationship between the treatment group and model group with thymus index and spleen index. Conclusion The result show that hematoxilin can significantly improve the immune functions of rats suffered from UC.
出处
《南华大学学报（医学版）》
2008年第4期433-435,共3页
Journal of Nanhua University(Medical Edition)
关键词
苏木水提物
溃疡性结肠炎
免疫调节
haematoxylin
Ulcerative colitis
immunogenic regulation
