摘要
目的 探讨射频消融治疗肝癌的临床疗效及安全性。方法 从1999年5月-2007年5月期间对1200例肝癌患者，其中原发性肝癌患者947例，转移性肝癌患者253例，在B超引导下进行集束电极射频消融治疗，通过手术前后对病灶采用CT、B超观测的比较，了解肿瘤大小、数量及血清AFP变化情况，通过术后观察和随访，了解其治疗疗效。结果1，本组病例的1年、3年和5年存活率分别为：67．48％、54．63％、35．82％；2，6月后病灶完全缓解（CR）：12．75％（153／1200）；部分缓解（PR）：74．33％（892／1200），总有效率为：87．08％；3，患者治疗后腹痛、腹胀症状减轻，生活质量明显提高；4，治疗后并发症少，未出现与治疗有关的死亡。结论：射频消融治疗小肝癌（直径≤5Cm）疗效较佳，对不能切除的大肝癌和转移性肝癌亦是一种高效、安全的治疗方法，其近、远期疗效确切。
Objective Investigate the clinical effectivencss of treatment in hepatoma by RFA with clustered electrode technique under ultrasound guided. Methods 1200 cases of hepatoma treat by radio frequency ablation under ultrasound guided transhepatic puncture technique, we observed the results by comparing preoperative and postoperative image data of tomor size underwent MR and CT scanning, the survival rate of 1,3,5 year and use the EORTC QLQ C-30 to evaluate the quality of life of the patient before and after the procedure. Results 1 ,the survival rate of 1,3 and 5 year are 67.48% ,54. 63% ,35.82% ;2, the effective power after the procedure 6 month are CR：12.75% （153/1200） ;PR：74. 33% （892/1200）, the total effective power：87. 08%. 3, after RFA 1 week AFP value increased,but after 2 week AFP value were decreased to normal. 4, the quality of life of the patient is raise obviously . Conclusion： ultrasound guided RFA thermal ablation of hepatoma is significant effects is safety and reliability.
出处
《肝胆外科杂志》
2008年第4期260-262,共3页
Journal of Hepatobiliary Surgery
基金
陕西省攻关课题(2004K17-G5)
关键词
肝癌
射频消融
集束电极
B超引导
存活率
hepatic tumor, radio-frequency ablation, eiustared electrode, uitrasoud guided, survival rate
