摘要
合并使用高渗盐液、右旋糖酐与山莨菪硷治疗家兔实验性严重失血性休克。结果显示:高渗盐液加右旋糖酐治疗组,平均动脉压、左室内压、左室内压变化速率、中心静脉压等血流动力学指标的恢复,显著优于等渗盐液治疗组;高渗盐液、右旋糖酐与山莨菪硷(5mg/kg)联用组,动脉血压回升后维持时间、中心静脉压升高的程度优于高渗盐液加右旋糖酐组。进一步证实联用高渗液与山莨菪硷可短时提高疗效,为抢救休克赢得时间。
Hemorrhagic shock was induced in rabbits by controlled arterial bleeding, to reduce and maintain mean arterial blood pressure at 5. 3 kPa for 30 min. The rabbits were then given 4ml/kg i. v. 1) isotonic NaCl (IS), 2) 7.5 NaC1/6% dextran 40 ( HS/DX), 3) 7.5% NaC1/6% dextran 40 + aniso-damine 5mg/kg ( HS/DX + 654-2). The results showed that MAP, LVP, dp/dt max and CVP were better improved in HS/DX and HS/DX+654-2 groups than in IS group, the MAP, CVP more effective in HS/DX + 654-2 group than in HS/DX group. The MDA/SOD ratio increased in IS and HS/DX group, but there was no significant change in HS/DX+654-2 group. Consequently, the oxygen-free radicals were produced in hemorrhagic shock. Anisodamine may have the effect against oxygen-free radicals directly or indirectly.
出处
《湖南医科大学学报》
CSCD
1990年第3期231-234,共4页
Bulletin of Hunan Medical University
关键词
休克
高渗盐液
右旋糖酐
山莨菪硷
shock, hemorragic
hypertonic solution
dextran
anisodamine
drug therapy
therapeutic use
rabbits
