摘要
本文报道50例癌肿患者外用血T淋巴细胞集落形成能力和T淋巴细胞亚群分布的改变。结果表明:癌肿患者的1.T淋巴细胞集落形成能力低下;2.OKT_4/OKT_8比值下降,部分倒置,3.血清及PHA淋巴细胞条件液可减少正常人T淋巴细胞集落的形成;4.~3H-TdR掺入淋巴细胞转化能力降低。
Changes of the ability of T lymphocyte colony formation and distribution of T lymphocyte subset of peripheral blood in 50 patients with malignant tumor was investigated. The results showed that in the patients with malignant tumor 1.the ability of T cell colony formation was depressed than that of the control group; 2. OKT8+ cells increased significantly and OKT4 / OKT8 ratic markedly reduced while OKT3+ cell and OKT4+ cells had no any abnormal variation; 3. Both sera and PHA-LCM (Lymphocyte conditioned medium, the supernatant liquid of mono-nuclear of colorectal cancer patients cultured with PHA for 72 h) could decrease the amount of T cell colony formation in the control group; 4. The response of 3H-TdR incorporation of lymphocyte transformation was lower than that of the control group.
出处
《湖南医科大学学报》
CSCD
1990年第2期127-130,共4页
Bulletin of Hunan Medical University
关键词
肿瘤
T细胞
集落形成
neoplasms
T lymphocytes
help cells
suppressor cells
colony-forming units assay
lymphocyte transformation
