摘要
目的:探讨胡桃楸乙醇提取物(AEBJ)对电离辐射所致小鼠免疫功能损伤的影响。方法:60只小鼠随机分为假照射组、照射对照组、AEBJ低剂量(300mg·kg-1)照射给药组、AEBJ高剂量(600mg·kg-1)照射给药组、AEBJ低剂量单纯给药组和AEBJ高剂量单纯给药组6个实验组,检测小鼠外周血白细胞数、淋巴细胞百分数、淋巴细胞绝对值、脏器指数和ConA刺激小鼠脾淋巴细胞增殖能力。结果:照射对照组小鼠外周血白细胞数、淋巴细胞绝对值、淋巴细胞百分数、脏器指数和ConA诱导的脾淋巴细胞增殖反应能力均低于假照射组(P<0.05);AEBJ高、低剂量照射给药组小鼠外周血白细胞数、淋巴细胞绝对值、淋巴细胞百分数、脏器指数和ConA诱导的脾淋巴细胞增殖反应能力均高于照射对照组(P<0.05);AEBJ高、低剂量单纯给药组的淋巴细胞百分数和ConA诱导的脾淋巴细胞增殖反应能力均高于假照射组(P<0.05)。结论:AEBJ对电离辐射所致的小鼠免疫功能损伤有保护和修复作用。
Objective To evaluate the effects of alcohol extract of Juglans mandshurica maxim （AEBJ） on immune function of ionizing irradiated mice. Methods The mice were randomly divided into normal control group, irradiating control group, low AEBJ （300 mg·kg^-1） irradiating group, high AEBJ （600 mg· kg^-1） irradiating group, low AEBJ plus drugs only group and high AEBJ plus drugs only group. The number of WBC and LYMPH, LYMPH%, viscera index, ability of lymphocytes transformation were examined. Results Compared with normal control group, the number of WBC and LYMPH, LYMPH% ,viscera index, ability of lymphocytes transformation in irradiating control group were decreased significantly （P〈 0.05）. Compared with irradiating control group, the number of WBC and LYMPH, LYMPH%, viscera index, ability of lymphocytes transformation in low AEBJ irradiating group and high AEBJ irradiating group were increased significantly （P〈0.05）. Compared with normal control group, LYMPH% and ability of lymphocyte transformation in low AEBJ plus drugs only group and high AEBJ plus drugs only group were increased significantly （P〈 0.05）. Oonclusion AEBJ has protective effects on immune function of ionizing irradiated mice.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2008年第1期120-123,共4页
Journal of Jilin University：Medicine Edition
基金
吉林省科技厅基金资助课题(990577-1)
关键词
胡桃楸
辐射损伤
免疫功能
脏器指数
刺激指数
juglans mandshurica maxim
irradiation injury
immune function
viscera index
stimulation index
