摘要
目的探讨ＰＳ２蛋白在乳腺浸润性癌中的表达及其与预后的关系。方法应用ＬＳＡＢ免疫组化法检测ＰＳ２蛋白在８６例乳腺浸润性癌中的表达。结果ＰＳ２蛋白的表达率为６６．２７％（５７／８６）。在下列一些情况中，ＰＳ２蛋白的表达率有区别：（１）８６例中，５年以上组８０．５５％（２９／３６），５年以下组５６．００％（２８／５０），差异有显著性意义（Ｐ＜０．０２５）；（２）未停经组６２例，５年以上组８６．２０（２５／２９），５年以下组５４．５４％（１８／３３），差异有显著性意义（Ｐ＜０．００５），已停经组２４例，５年以上组４／７例，５年以下组５８．８０％（１０／１７），差异无显著性意义；（３）腋窝淋巴结转移６２例，５年以上组８２．３５％（１４／１７），５年以下组５５．５５％（２５／４５），差异有显著性意义（Ｐ＜０．０５）；腋窝淋巴结阴性２４例，５年以上组７８．９４％（１５／１９），５年以内组３／５例，差异无显著性意义。结论本研究表明，ＰＳ２蛋白的阳性表达与５年生存期正相关，ＰＳ２阳性的表达可以作为乳腺癌的一项预后指标；ＰＳ２蛋白表达对未停经患者的内分泌治疗具有一定的指导意义；腋窝淋巴结阳性患者ＰＳ２蛋白表达与较好的预后相关。
Objective To study the relationship between the expression of PS2 protein and prognosis in the invasive breast cancer (IBC). Method Using LSAB immunohistochemical method, PS2 protein expression in 86 cases of IBC was detected. Results The positive rate of PS2 protein was 66.27%(57/86) in 86 cases of IBC. Under the following 3 conditions, PS2 protein expression levels in the morethan5yearsurvival group (A) were higher than those in the lessthan5yearsurvival group (B). (1) In 86 cases of IBC, the expression level was 80.55%(29/36) for Group A, Significantly different from the 56.00%(28/50) of Group B (P<0.025). (2) In 62 cases of premenopausal patients, the corresponding data were 86.20%(25/29) and 54.54%(18/33) respectively, P<0.005; whereas in 24 cases of postmenopausal patients, 4/7 and 58.82%(10/17) respectively, P>0.5. (3) In 62 cases of axillary node positive patients, the expression levels for Groups A and B were 82.35% (14/17) and 55.55%(25/45) respectively, P<0.05; while in 24 cases of axillary node negative patients, 78.94%(15/19) and (3/5) respectively, P>0.5. Conclusions These results suggest that the expression of PS2 protein was positively correlated with 5yearsurvival in IBC, and could be considered as a prognostic predictor for breast cancer, PS2 protein expression was a useful indicator for endocrine therapy in premenopausal patients. In axillary node positive patients, the expression of PS2 protein was associated with a better prognosis.
出处
《中华病理学杂志》
CAS
CSCD
北大核心
1997年第6期331-333,共3页
Chinese Journal of Pathology
基金
广州市卫生局科研基金
