摘要
目的研究替比夫定治疗慢性乙型重型肝炎的疗效。方法将12例慢性乙型重型肝炎患者应用替比夫定抗病毒治疗,其中10例联合人工肝治疗,观察治疗效果。结果替比夫定可使HBV-DNA载量下降,凝血酶原活动度好转;7例应用后2周出现血清总胆红素(TBIL)升高,其中4例于抗病毒治疗6周后,并结合内科综合治疗、血浆置换治疗,TBIL持续大于205μmol/L,其中1例行肝移植治疗;9例患者于应用后2周出现血清丙氨酸转移酶(ALT)升高。结论替比夫定可明显抑制重型乙型肝炎病毒复制,部分患者有肝功能波动,需密切观察肝功能变化并及时调整综合治疗。
Objective To observe the clinical effect of telbivudine therapy on severe hepatitis B. Methods Twelve patients with severe hepatitis B was given telbivudine, 10 patients of them combined with artificial liver. Results In patients with telbivudine HBV-DNA negative sero-conversion rat decreased, PTA increased. There was obviously decreasing in TBIL about 7 patients after 2 weeks, after 6 weeks treatment（ telbivudine combined with artificial liver and basing treatment） there was above 205μmol/L in TBIL about 4 patients, liver transplantation was given to one of them. After 2 weeks treatment there was obviously decreasing in ALT about 9 patients. Conclusion Telbivudine can effectively in- hibit HBV replication, liver injury would be happen in some of patients with telbivudine, we must be observed in them, so that we can square the treatment.
出处
《胃肠病学和肝病学杂志》
CAS
2008年第8期662-664,共3页
Chinese Journal of Gastroenterology and Hepatology
