摘要
目的:研究慢性乙型重型肝炎血清病毒载量与肝损伤的关系。方法:临床收集102例慢性乙型重型肝炎患者血清标本治疗前后测定其血清HBV标志物,用荧光定量PCR仪检测HBVDNA含量,肝功能及生化指标和凝血酶原时间均由本院生化仪测定,将慢性乙型重型肝炎比较早期,中期,晚期治疗前后病毒载量情况和肝功能生化指标比较。结果:重型肝炎早期中期病毒载量高,治疗前后病毒对比有明显差异,晚期则无明显差异;治愈组病毒阴转率明显高于死亡组;病毒载量与肝损伤程度无明显差异。结论:慢性乙型重型肝炎病毒载量与肝损伤程度无明显相关,但病毒阴转率是提高治愈率重要因素之一。
Objective：To explore the relationship between the content of HBV DNA in the serum and the liver function state in patients suffering from chronic gravis of hepatitis B. Methods. HBV markers and HBV DNA in the serum of 102 patients were detected by ELISA and FQ2PCR respectively. Biochemistry autoanalysis system was used for determination of liver function in 102 patients with chronic serious hepatitis B. Results：The virus loading of hepatitis gravis in the early-middle time had obvious different from the loading at the end of treatment（P〈0.05）, and lately time of hepatitis gravis had no changes. The percentage of the virus marker negative in cured patients was higher than that in dead patients. The HBV DNA loading was not related to hepatic damage（P〉0.05）. Conclusion：There is no obvious correlation between hepatic damage and HBV DNA, but the virus marker negative is one of important factor of cure patients.
出处
《实用临床医学（江西）》
CAS
2006年第1期12-14,共3页
Practical Clinical Medicine
基金
江西省卫生厅课题(G010520)
