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胰腺癌基础研究的现状与展望 被引量:3

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摘要 胰腺癌是腹部肿瘤中恶性程度最高,预后最差的肿瘤。由于胰腺的解剖位置和胰腺癌独特的生物学特性,导致其早期诊断困难,80%以上的病人就诊时已属中晚期,失去了行根治性手术的机会,即使获得手术切除的病人,术后5年生存率也仅为5%左右。虽然现代外科技术的发展使胰十二指肠切除术围手术期病死率降至5%以下,但30年来胰腺癌的长期存活率并未发生显著变化。如何进一步提高胰腺癌的早期诊断率和长期存活率,是所有胰腺癌基础和临床研究工作者必须长期面对的现实问题。在胰腺癌临床治疗短期内难以获得突破的形势下,胰腺癌的相关基础研究显得尤为重要,同时要重视科研成果的快速转化,使实验研究迅速步入临床,从而提高胰腺癌的疗效,改善病人的生存质量。
出处 《中华医学杂志》 CAS CSCD 北大核心 2008年第28期1945-1947,共3页 National Medical Journal of China
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