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吉西他滨加卡铂联合化疗治疗老年晚期非小细胞肺癌临床研究 被引量：7

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摘要 目的观察吉西他滨与卡铂联合化疗方案治疗老年晚期非小细胞肺癌(NSCLC)患者的临床疗效及不良反应。并与长春瑞滨联合卡铂方案比较,探索适合老年人NSCIC的治疗方案。方法对住院治疗的65例老年NSCLC患者随机分为2组,分别采用吉西他滨加卡铂(GC)和长春瑞滨加卡铂(NC)的联合化疗方案进行化疗,按WHO疗效及毒副反应评价标准,对完成2个周期以上治疗的患者进行临床疗效及不良反应评价。结果GC和NC方案有效率分别为45.7%和43.3%(P>0.05);平均生存期分别为8.2个月和7.5个月,1年生存率分别为37.1%和33.3%(P>0.05)。2种化疗方案的主要毒副反应为骨髓抑制,其中在Ⅲ度以上白细胞和血小板下降方面,2组差异有统计学意义(P<0.05)。结论吉西他滨与卡铂联合化疗方案治疗老年NSCLC患者的临床疗效较好,不良反应较轻,患者的耐受性好。
作者 吴康 李树勇 吴涛
机构地区 山东省临清市人民医院肿瘤科
出处 《河北医药》 CAS 2008年第9期1312-1313,共2页 Hebei Medical Journal
关键词 非小细胞肺癌 化学疗法 吉西他滨 卡铂
分类号 R734 [医药卫生—肿瘤] R734.2 [医药卫生—肿瘤]
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参考文献5

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共引文献13

同被引文献41

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二级引证文献61

河北医药
2008年 第9期

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