摘要
目的探讨放化疗不同联合模式对治疗非小细胞肺癌患者生活质量的影响。方法将151例经病理确诊的非小细胞肺癌患者按照治疗模式不同分为3组,同步放化疗组(43例)、序贯放化疗组(49例)及单纯化疗组(59例),在治疗前、后及治疗结束后1个月应用欧洲癌症研究与治疗组织(European Organization For Research Treat-ment Of Cancer,EORTC)生活质量核心问卷(QLQ-C30)对患者生存质量进行评估。结果在角色功能、情绪功能、社会功能、疲倦、恶心/呕吐、便秘方面,同步放化疗组与序贯放化疗组在治疗后积分均恶化,差异有统计学意义(P<0.05),在治疗结束后1个月两组患者积分均明显改善,差异有统计学意义(P<0.05),而单纯化疗组的社会功能在治疗结束及治疗后1个月均出现恶化,差异有统计学意义(P<0.05),恶心/呕吐、情绪功能在治疗后1个月得到改善,差异有统计学意义(P<0.05);角色功能、疲倦、便秘方面,治疗前后及治疗后1个月无明显改变(P>0.05),在躯体功能领域中同步放化疗组在治疗结束时恶化,差异有统计学意义(P<0.05),序贯放化疗组改善,差异有统计学意义(P<0.05),而在治疗结束1个月同步放化疗组改善,差异有统计学意义(P<0.05),序贯放化疗组恶化,差异有统计学意义(P<0.05);总体健康状况同步放化疗组在治疗结束1个月均得到改善,差异有统计学意义(P<0.05),而在序贯放化疗组治疗结束1个月恶化,差异有统计学意义(P<0.05),单纯化疗组则无明显变化(P>0.05);经济状况在3个组均在治疗结束及结束后1个月出现恶化,差异有统计学意义(P<0.05)。结论同期放化疗相对于单纯化疗、序贯放化疗而言,虽在治疗刚结束时躯体、角色等功能会有所下降,疲乏、恶心/呕吐等症状会加重,但在治疗后1个月这些功能、症状均得到不同的改善,总健康状况也得到明显提高。
Objective To investigate the influence of quality of life（QOL） of non-small cell lung cancer（NSCLC） patients by different combined styles of radiotherapy and chemotherapy. Methods Totally 151 patients with NSCLC were divided into three groups： concurrent chemo-radiotherapy group（n=43）,sequential chemo-radiotherapy group（n=49） and chemotherapy only group（n=59）.The QOL of patients were evaluated and analyzed by European Organization for Research and Treatment of Cancer′s Quality of Life Questionnaire-Core（EORTC QLQ-C30） before therapy,after therapy（4th week） and 1 month after therapy. Results The scores of QLQ were worse in role function,emotion function,social function,fatigue,vomiting,nausea,and constipation in the concurrent chemo-radiotherapy group and sequential chemo-radiotherapy group 1 day after therapy（P0.05）,but the scores of QLQ were better in the two group 1 month after therapy（P0.05） In the chemotherapy only group,the score of QLQ was worse in social function 1 day and 1 month after therapy（P0.05）;the scores of QLQ were better in vomiting,nausea,emotion function 1 month after therapy（P0.05）;and there were no obvious changes in role function,fatigue,and constipation scores of QLQ 1 day and 1 month after therapy（P0.05）.The score of QLQ was worse in body function in the concurrent chemo-radiotherapy group（P0.05） 1 day after therapy,but it was better in the sequential chemo-radiotherapy group（P0.05） 1 day after therapy.The score of QLQ was better in body function in the concurrent chemo-radiotherapy group（P0.05） 1 month after therapy（P0.05）,but it was worse in the sequential chemo-radiotherapy group（P0.05） 1 month after therapy.The score of QLQ was better in total health situation in the concurrent chemo-radiotherapy group（P0.05） 1 month after therapy,but it was worse in the sequential chemo-radiotherapy group（P0.05）,and it was of no significant change in the sequential chemo-radiotherapy group（P0.05）.The score of QLQ was worse in economical situation in all the three group（P0.05） 1day after therapy and 1month after therapy. Conclusion Compared with the chemotherapy only and sequential chemo-radiotherapy,although the scores of QLQ could be worse in body function and role function were decreased,and the symptoms of fatigue,nausea and vomiting become worse 1 day after therapy,the concurrent chemo-radiotherapy can improve all the functions and symptoms after I mouth therapy,and the total health level was also be evidently increased.
出处
《中国全科医学》
CAS
CSCD
北大核心
2011年第4期381-384,387,共5页
Chinese General Practice
关键词
非小细胞肺癌
放疗
化疗
生活质量
Carcinoma
non-small cell lung
Radiotherapy
Chemotherapy
Quality of life
