摘要
目的观察激素性股骨头坏死兔在高压氧治疗前后凝血-纤溶系统指标含量的变化，以探讨早期高压氧治疗激素性股骨头坏死的作用机制。方法建立激素性股骨头坏死的动物模型，各组分别采血测定血浆抗凝血酶Ⅲ（AT-IU）、血栓调节蛋白（TM）、组织型纤溶酶原激活物（tPA）、纤溶酶原激活物抑制剂-1（PAI-1）的含量。结果4周和6周时高压氧组AT-IU含量较模型组升高，差异有统计学意义（P〈0.01）；1周时高压氧组TM含量较模型组降低，差异有统计学意义（P〈0.05），4周时升高，差异有统计学意义（P〈0.05）；2周时高压氧组tPA含量较模型组升高，差异有统计学意义（P〈0.05）；2周时高压氧组PAI-1含量较模型组降低，差异有统计学意义（P〈0.05）。结论早期高压氧治疗可以减轻激素性股骨头坏死模型动物的血管内皮的损伤，促进抗凝因子的合成、释放和纤维蛋白溶解，从而改善机体高凝状态。
Objective To observe the changes of contents of indexes of coagulation-fibrinolysis systems of steroid-induced avascular necrosis of femoral head （SANFH） in rabbits before and after hyperbaric oxygen （HBO） treatment and to investigate the mechanism of action of early HBO treatment on SANFH . Methods Animal models of steroid-induced avascular necrosis of femoral head were established, then contents of antithrombin-Ⅲ （ AT-Ⅲ）, thrombomodulin （ TM ）, tissue-type plasminogen activator （ tPA ） and plasminogen activator inhibitor-1 （ PAl-1 ） were measured in each group respectively. Results The content of AT-Ⅲ in HBO group was significantly higher than that in model group at four and six weeks（P〈0.01）. The content of TM in HBO group was significantly lower than that in model group at one week （P〈0.05）, whereas higher at four weeks（P〈0.05）. At two weeks, the content of tPA in HBO group was significantly higher than that in model group（P〈0.05）, whereas that of PAl-1 lower （P〈0.05）. Conclusions Early HBO therapy can relieve endothelial cell injury of blood vessel, promote synthesize and discharge of anticoagulative factor and accelerate dissolution of fibrin, which improve hypercoagulability state of model animals of SANFH.
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2008年第3期146-148,共3页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
基金
基金项目：北京市科委首都特色临床医学技术发展研究项目（Y0905001000091）
关键词
高压氧
激素性股骨头坏死
抗凝血酶Ⅲ
血栓调节蛋白
组织型纤溶酶原激活物
纤溶酶原激活物抑制剂-1
Hyperbaric oxygen
Steroid-induced avascular necrosis of femoral head
Antithrombin-Ⅲ
Thrombomodulin
Tissue-type plasminogen activator
Plasminogen activator inhibitor-1
