摘要
目的：探讨抗菌药物应用量与细菌耐药性之间的关系，为合理应用抗菌药物提供参考依据。方法：统计某医院2005-2006年18种常用抗菌药物的用药频度，计算相关系数，描述用药频度与细菌耐药性之间的相关性及相关密切程度。结果：细菌对18种抗菌药物的耐药率与其用药频度的相关系数在0.6101～0．9730之间，相关均具显著性。结论：细菌耐药率与抗菌药物的用药频度呈正相关。应多方并举加强抗菌药物管理，合理使用抗菌药物，减少细菌耐药性的发生，提高临床抗感染治疗的效果。
OBJECTIVE： To discuss the use of antibacterials and the bacterial drug resistance for reference of rational use of antibacterials. METHODS： The DDDs of 18 commonly used antibacterials in one hospital during the period from 2005 to 2006 were analyzed statistically, and the correlation between the use of antibacterials and the bacterial drug resistance were derived by computing the correlation coefficient. RESULTS： The correlation coefficient r between DDDs of 18 antibacterials and the bacterial drug resistance rate ranged from 0.610 1 to 0.973 0, and which was of significant difference. CONCLUSION ： There is a positive correlation between DDDs of antibacterials and the bacterial drug resistance. Hospital should strengthen the administration o{ antibacterials at different angle to promote rational use of antibacteirals, reduce bacterial resistance and enhance the curative effect of anti -infective therapy.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第20期1557-1558,共2页
China Pharmacy
关键词
抗菌药物
耐药性
关系
探讨
Antibaterials
Drug resistance
Correlation
Discussion
