摘要
为探讨化妆品皮炎的发病机制，对３种香料（异丁香酚、肉桂醛、羟基香茅醛）进行皮肤刺激、皮肤变态反应及离体皮肤渗透的动物实验研究。结果显示：３种香料均是强致敏原，其中肉桂醛还具刺激性。三种香料均能经皮渗透，其中肉桂醛的皮肤渗透性最强；提示化妆品引起的接触性皮炎可能原发刺激与变态反应两种机制同时存在；
Purpose: To find out the mechanism of cosmetic related dermatitis. Methods: 3 perfumes commonly used in cosmetics were selected (isoeugenol, cinnamic aldehyde and hydroxycitronellal) for laboratory studies of acute skin irritation test (ASIT), multi irritation skin test (MIST), skin sensitization test (GPMT) and percutaneous penetration in vitro in experimental animals were performed respectively. Results: ASIT showed that none of the three chemicals was irritative. MIST revealed that cinnamic aldehyde was an irritant, and the others were not, the average index of skin irritation was consistent with the severity of histopathologic changes. GPMT showed all of the three chemicals were strong sensitizers. Percutaneous penetration of three kinds of perfumes in vitro showed all of them could be absorbed more or less, and the amount, rate and velocity of penetration of cinnamic aldehyde were the highest among them. Conclusion: The mechanism of cosmetic related dermatitis may be due to primary irritation and/or allergy. The potency of skin sensitization of a chemical is related to its percutaneous penetration.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1997年第5期318-320,共3页
Chinese Journal of Dermatology
基金
国家教委博士点基金
关键词
皮肤刺激
致敏反应
离体皮肤渗透
香料
Irritation Sensitization Percutaneous penetration Perfume
