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Caveolin-1和Wnt信号通路与消化道肿瘤

Relationship between caveolin-1 and wnt signaling pathway and digestive tract tumors
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摘要 Caveolae是直径为50-100nm的细胞表面特异性内陷结构，caveolin-1是caveolae的主要成分。Caveolin-1具有脚手架结构，在体外和原位能结合和抑制几种信使蛋白，与多种消化道肿瘤相关。Wnt／β-catenin途径涉及到多个部位的肿瘤发生。Caveolin-1能通过Wnt信号途径抑制肿瘤发生。 Caveolae are 50-100nm vesicular invaginations of plasma membrane and caveolin-1 is a principal component of caveolae membranes. Caveolin-1 contains a so-called scaffolding domain that binds to and inhibits the activity of several signaling proteins in vitro and in situ. Caveolin-1 is related to several digestive tract tumors. The Wnt signaling pathway has been implicated in tumorigenesis at several sites. Caveolin-1 can inhibit tumorigenesis through Wnt signaling pathway.
作者 吴军霞 吴建胜 金嵘
机构地区 温州医学院附属第一医院消化内科 温州医学院附属第一医院流行病学教研室
出处 《国际消化病杂志》 CAS 2008年第3期197-198,190,共3页 International Journal of Digestive Diseases
基金 浙江省自然科学基金(项目编号Y206750)
关键词 CAVEOLIN-1 WNT信号通路 消化道肿瘤 Caveolin-1 Wnt signaling pathway Digestive tract tumors
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献15

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二级参考文献11

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国际消化病杂志
2008年 第3期

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