摘要
目的:探讨血浆同型半胱氨酸(HCY)水平与脑梗死发生以及颈动脉硬化,斑块形成,颈动脉狭窄之间的关系。方法:对204例急性脑梗死患者和40例健康对照者,采用荧光偏振免疫法测定血浆HCY,彩色多普勒超声检查颈动脉内膜厚度,有无斑块,狭窄,同时用直径法计算狭窄率。结果:脑梗死患者血浆HCY平均水平(17.69±10.07)μmol/L,显著高于对照组(10.29±3.29)μmol/L(P=0.00)。脑梗死组中伴颈动脉斑块的患者HCY水平高于无颈动脉斑块者,呈逐渐上升趋势,经检验显示A、B、C各组与正常组比较有显著性差异(P<0.05)。按血清HCY水平不同分为正常、轻度、中度、重度升高,血管狭窄分为正常、A、B、C组,做相关分析,Spearman相关系数为0.443(P=0.00),呈显著正相关。表明HCY水平与颈动脉狭窄程度显著相关。结论:高同型半胱氨酸血症与脑梗死,颈动脉斑块的发生有一定的关系;HCY水平与颈动脉狭窄程度呈显著正相关。
Objective： To study the relationship between levels of plasma homocysteine and acute cerebral infarction, carotid artery atherosclerosis and carotid stenosis. Methods： Levels of plasma homocysteine were measured by fluorescence polarization immunoassay in 204 acute cerebral infarction patients and 40 healthy subjects, the carotid intima-media thickness, the plaque and the carotid stenosis were assessed by color Doppler ultrasound. The rate of stenosis was calculated by diameter. Results： The levels of homocysteine in acute cerebral infarction group were significantly higher than those in healthy control group（P〈0.01 ）. The homocysteine levels in the group of patients with carotid artery plaque were higher than those without plaque, and also showed an increased tendency . According to the different levels of serum homocysteine divided into normal、mild、moderate severe group , based on the carotid stenosis divided into normal group and A、B、C group. Spearman correlation between levels of serum homocysteine and carotid stenosis, the correlative coefficient is 0. 443 （P = 0.00）. Conclusion： The level of homocysteine was correlated with carotid artery plaque and acute cerebral infarction. There was a significantly correlation between levels of serum homocysteine and carotid stenosis.
出处
《内蒙古医学杂志》
2008年第5期540-542,共3页
Inner Mongolia Medical Journal
