摘要
目的探讨急性脑梗死患者血清同型半胱氨酸(Hcy)水平与颈动脉粥样硬化程度的关系。方法选择住院确诊为急性脑梗死患者144例,行颈动脉超声多普勒检查,根据颈动脉超声检查的结果分为颈动脉中-重度狭窄组、颈动脉轻度狭窄组、颈动脉内膜正常组,应用微粒子酶联免疫分析法(MEIA)测定Hcy并进行组间比较。结果颈动脉中-重度狭窄组的Hcy水平为(32.69±19.54)μmol/L,高于颈动脉内膜正常组(17.14±4.98)μmol/L和颈动脉轻度狭窄组(24.72±10.53)μmol/L,有非常显著性差异(P﹤0.01)。颈动脉轻度狭窄组和颈动脉内膜正常组血清Hcy水平有显著性差异(P﹤0.05)。各年龄组间狭窄程度无显著性差异,但50岁以上的老年患者颈动脉狭窄率明显高于50岁以下者(P﹤0.01)。结论高Hcy血症可能通过加速动脉粥样硬化而导致脑梗死,血Hcy水平与动脉粥样硬化程度相关,将二者结合起来,对急性脑梗死的预防、治疗及判断预后有重要意义。
Objective To study the relationship between serum homocysteine （Hey） levels and carotid artery atherosclerosis （CAA） in cerebral infarction patients. Methods Patients with cerebral infarction were examined by color Doppler ultrasonography to detect CAA stenosis. The patients were divided into three groups based on the severity of stenosis of CAA： the moderate-severe stenosis group, the slight stenosis group, and the normal group. The results of serum Hey levels on different groups were compared. Results The Hey level of moderate-severe group was （32.69±19.54） μmol/L, while the Hey level of normal group was （17.14±4.98） μmol/L, and the Hey level of the slight stenosis group was （24.72±10.53）μmol/L. There was statistically significant difference of Hey level between the moderate-severe stenotsis group and the other two groups （P 〈 0.01 ）, and there was also statistically significant difference of Hey levels between the slight stenosis group and the normal group （P 〈 0.05）. While the degree of stenosis on different age groups was not significantly different （P 〉 0.05）, but the incidence of carotid artery stenosis in patients more than fifty was significantly higher than it was in other patients （P 〈 0.01）. Conclusions Hyperhomocysteinemia may accelerates atherosclerosis that results in cerebral infarctions. Homoeysteinaemia level is highly correlated with the severity of the stenosis of CAA. The measurement of CAA combined with Hey is very important for treatment and the prognosis of patients with cerebral infarction.
出处
《北京医学》
CAS
2007年第7期385-387,共3页
Beijing Medical Journal
