摘要
肝细胞癌(HCC)患者总生存时间很短,目前尚无有效的二级预防和全身治疗。环氧化酶-2(COX-2)催化产生的前列腺素E2(PGE2)信号为HCC提供新的治疗具有重要的意义。本综述总结COX-2-PGE2-PGE2受体信号在HCC发生的机制,为有效的化学预防及新的治疗策略提供思路。
The overall survival of patients with hepatocellular carcinoma is very grim and currently no emcient secondary pre- vention or systemic treatments are available. The recently delin- eated COX-2-defived PGE2 signaling is expected to provide im- portant therapeutic implications. This review summarizes the re- cent advances in understanding the mechanisms for COX-2-PGE2- PGE2 receptor signaling in hepatocarcinogenesis. Understanding these mechanisms will facilitate the development of more effective chemopreventive and therapeutic strategies.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2008年第5期561-564,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金(No:30572356)
高等学校博士学科点专项科研基金(No:20060366003)
安徽高校科技创新团队基金(2005TD003)
安徽省研究实验基地优秀中青年科研带头人基金(200622805)资助项目
