摘要
Fever is an adaptive host response coordinated by the central nervous system （CNS） during systemic immune challenge. Recent research shed light on the mechanism of fever generation, particularly the underlying neural pathways. In this review, we first briefly summarize current views on the mechanism of sensing microbial infection by the nervous system, and the roles of prostaglandin E2 （PGE2） and its receptors in fever; then we focus on the neural circuits underlying fever generation, particularly their relationship with the distribution of PGE2 receptors within the CNS. At the end, an overall neurochemical model of fever generation is presented, pointing to the direction for future studies.
发热是在宿主中枢神经协调下的对周身感染的适应性反应。近期对发热产生机制(尤其是导致发热的神经解剖通路)的研究取得了很大进展。在本文中,我们简要陈述目前对中枢神经对周边感染的监测机制的认识,以及E2类前列腺素及其受体在发热中的作用;着重阐述了发热产生的神经通路,尤其是这一通路与E2类前列腺素受体在中枢神经内的相互分布关系。最后,我们展示了一个发热产生的神经化学模型,并指出未来研究工作的方向。
