摘要
目的：探讨中医肾阴虚与下丘脑弓状核毁坏后中枢单胺类递质代谢的关系。方法；用谷氨酸单钠（ＭＳＧ，出生后２、４、６、８、１０天，４ｍｇ／ｇ皮下注射）造成大鼠弓状核毁坏后继发性下丘脑－垂体－肾上腺（ＨＰＡ）轴功能亢进模型，观察其下丘脑单胺类递质含量和体重增长的变化。结果：新生期大鼠给予ＭＳＧ，成年后下丘脑单胺类递质中多巴胺、去甲肾上腺素等含量显著降低；同时还表现体重减轻、肥胖、鼻－肛长度缩短等生长受抑现象。滋补肾阴名方左归丸能不同程度改善上述异常指标。结论：ＭＳＧ大鼠中枢单胺类递质的代谢异常与中医肾阴虚相关。
To evaluate the interrelationship between the traditional Chinese medicine the Kidney-Yin Deficiency Syndrome and the metabolism of hypothalamic monoaminic neurotransmitters after the lesion of arcuate nucleus (ARC). Methods: Rats were injected with monosodium glutamate(MSG, at 2, 4, 6, 8, 10 days after born. 4mg/g body weight, s.c.)during the neonatal period, then the contents of hypothalamic monoaminic transmitters were determined with HPLC and the changes of increase of body weight were observed. Results: Decreases in levels of norepinephrine (NE), dopamine (DA) associated with its metabolite, 3, 4-dihydroxyphenyl acetic acid (DOPAC) were observed, while vanillylmandelic acid(VMA), metabolite of NE, serotonin (5-HT)and 5-hydroxyindole acetic acid (5-HIAA)were unchanged. Furthermore, adult rats with neonatal MSG treatment also demonstrated growth retardation, obesity but lower body weight, and shorter length of naso-anal. Zuogui Wan, classical drugs of nourishing and recuperating the Kidney-Yin, relieved the disorder of the metabolism of hypothalamic monoaminic transmitter in MSG-rats. Conclusion: The metabolic disorders of the central monoaminic transmitters may be related with the Deficiency of the Kidney-Yin.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1997年第11期673-675,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金
卫生部科学基金
关键词
肾阴虚
左旋谷氨酸单钠
单胺类递质
左归丸
monosodium glutamate
hypothalamus
monoaminic transmitters
Zuogui Wan
nourishing and recuperating the Kidney-Yin
