摘要
新生期大鼠给予左旋谷氨酸单钠（ＭＳＧ）损害下丘脑弓状核（ＡＲＣ），成年后大鼠除表现生长发育迟缓外，还可见到胸腺体积缩小、重量减轻，脾脏Ｔ淋巴细胞对Ｃｏｎ－Ａ诱导的增殖反应减弱。滋补肾阴代表名方左归丸能明显改善ＭＳＧ－大鼠的胸腺与淋巴细胞增殖反应的异常。提示：１．下丘脑弓状核参与细胞免疫功能的调节；２．
The adult rats that were treated with monosodium glutamate (MSG) neonatally to cause a lesion of arcuate nucleus (ARC) in the hypothalamus, showed smaller and lighter thymus and inhibited spleen T lymphocyte proliferation (LPR), apart from retarded growth. After the treatment with the adult MSG rats with Zuogui pill, a TCM presoription nourishing and recuperating the Kidney Yin, we found inhibited cellular immunity was reversed to some extent.It suggested 1.ARC may be a regulator of cellular immunity; 2.Zuogui pill can redress the abnomality of the thymus and LPR.
出处
《中国实验方剂学杂志》
CAS
1998年第4期1-3,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金
卫生部科学研究基金
关键词
左归丸
胸腺
弓状核
淋巴细胞增殖
MSG
Zuogui Pill, arcuate nucleus, monosodium glutamate, lymphocyte proliferation
