摘要
采用Heron袖套法进行异种（小鼠→大鼠）心脏移植，异位移植于颈部皮下，供体主动脉接受体颈内动脉，供体肺动脉接受体项外静脉，并对手术方法进行了部分改进。进行正式手术22次，成功率86％，移植后平均存活时间2．10±0．80天；该方法简单、迅速、可靠，移植于颈部易于观察，对于超急性排斥反应的观察以及免疫耐受的诱导，抗免疫排斥药物筛选是一位得推广的动物模型。
The mouse heart was transplanted into the neck of rat using the cuff technique described by Heron with a little modification. The graft accending aorta to the host common carotiel artery and the graft pulmonary artery to the host exteral jugular vein were performed. 22 times of formal transplantation were done with the successful rate being 86%. The mean survival time was 2 .10±0. 80 days. The method is easy, quick and reliable- The superficial cervical localigation of the transplant is easily observed. This is a good model to observe the hyperacute rejection(HAR),to induce the translantation tolerance, and to screen the new immunosuppressive agents.
出处
《中华器官移植杂志》
CAS
CSCD
1997年第4期212-213,共2页
Chinese Journal of Organ Transplantation
关键词
异种移植
袖套法
心脏移植
Cuff technique
Heart
Xenotransplantation
