摘要
目的探讨血清γ-球蛋白在评估肝脏储备功能中的作用。方法对30例肝脏肿瘤切除术的患者术前进行肝功能分级以及血清蛋白电泳检查,分析γ-球蛋白与手术前、后肝功能Child-Pugh分级的关系,以及用血清γ-球蛋白作为评估标准与肝功能Child-Pugh分级的符合程度。结果术前肝功能Child-Pugh分级A级的26例患者血清γ-球蛋白为(21.053 3±6.001 4)%,明显低于4例B级患者的(28.800 0±8.672 5)%,差异有统计学意义(P<0.05);术后肝功能Child-Pugh分级A级的25例患者术前血清γ-球蛋白为(21.022 0±5.354 6)%,明显低于5例B、C级患者的(29.556 0±7.698 5)%,差异同样有统计学意义(P<0.05);以血清γ-球蛋白>30%作为预测术后肝功能代偿不良的标准,其敏感性(80.00%)、特异性(96.00%)都较好。结论术前患者血清γ-球蛋白可以反映其肝脏储备功能,结合患者术前血清γ-球蛋白监测结果和肝功能Child-Pugh分级能够更客观地评估肝脏占位病变患者肝脏储备功能情况。
Objective To explore the effect of gamma-globulin in evaluating hepatic functional reservation in patients with liver tumor. Methods Serum protein electrophoresis （SPE） was performed on 30 patients with liver tumor to get gamma-globulin and preoperative Child-Pugh classification. Then the relations between gamma-globulin and preoperative and postoperative Child-Pugh classification were studied, While with gamma-globulin as evaluating standard, the validity compared with Child-Pugh classification were studied. Results The gamma-globulin was low- er in classification A patients [（21,053 3±6. 001 4）%3 than that in classification B [（28,800 0±8. 672 5）%3 before operation. While the gamma-globulin [（21,022 0±5. 354 6）% ] of classification A patients after operation was also lower than that of classification B/C [（29.556 0±7.698 5）%]. These differences were significant （P〈0.05）. With gamma-globulin 〉30 % as evaluating standard, the sensitivity and specificity were 80.00 % and 96.00 %, respectively. Conclusion Gamma-globulin can reflect hepatic functional reservation in patients with liver tumor. Combining gamma-globulin and Child-Pugh classification can evaluate hepatic functional reservation more objectively.
出处
《中国普外基础与临床杂志》
CAS
2008年第4期274-277,共4页
Chinese Journal of Bases and Clinics In General Surgery
关键词
γ-球蛋白
肝功能
肝脏储备功能
Gamma-globulin Liver function Hepatic functional reservation
