摘要
目的:探讨核糖核酸对肝脏移植后患者肝功能恢复、HBV DNA滴度下降,γ-球蛋白值复常的作用。方法:将病人分为Control组、HGF组、RNA组,分别采用基础治疗、基础治疗+肝细胞生长因子、基础治疗+核糖核酸3种治疗方法。观察术后2周和1月时患者肝功能(ALT、TBil、Alb、PT)、HBV DNA滴度、γ-球蛋白比例。结果:RNA组和HGF组在降低ALT、TBil等方面基本相同、但HGF组在改善血清白蛋白水平和促进凝血因子合成方面较RNA组稍差。RNA组γ-球蛋白比例下降与Control组无差异,但有下降较多的趋势。RNA组术后1月内的病毒复制指标较Contor组和HGF组降低,但不存在统计学上差异。结论:核糖核酸可促进肝脏移植后患者肝功能恢复、降低HBV DNA滴度和γ-球蛋白比例,在肝脏移植后应用它能获得良好效果。
Objective: To explorer the benefit of RNA abministration to liver transplant recipients recovery (liver function, litre of HBV DNA and γ-globulin) . Methods: Classified 39 liver recipients according to treatment protocol (basic treatment, added HGF treatment, adbed RNA treatment) as control group, HGF group and RNA group. ALT, TBil, Albumin, PT, titre of HBV DNA and γ-globulin were detected in two weeks and one month after transplantation. Results: RNA group and HGF group have the same effect on decreasing level of ALT and T-bil as well as RNA has better effect on increase albumin and coagulation factors than HGF. RNA group has the tendency on decreasing 7-globulin but show no statistics difference with Control group. The titre of HBV DNA in RNA group is lower than Control group and HGF group. Conclusion: RNA administration has satisfied effect on recovery of liver transplant recipients including improving liver function, decreasing titer of HBV DNA and γ-globulin.
出处
《中西医结合肝病杂志》
CAS
2002年第6期334-336,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
关键词
核糖核酸
肝脏移植
恢复
RNA
Live Transplantation
Recovery
