摘要
目的探讨老年铜绿假单胞菌性肺炎患者的细胞免疫功能状态。方法采用免疫荧光标志和流式细胞仪技术对35例老年铜绿假单胞菌性肺炎患者的外周血淋巴细胞亚群表面标志物的表达进行分析,以35例健康老年人作为对照组。结果与对照组比较,老年铜绿假单胞菌性肺炎患者的CD4+/CD3+、CD25+/CD3+,明显降低(P<0.05),CD4+/CD8+、HLA-DR+/CD3+、CD16+56+/CD3-显著性降低(P<0.01),CD8+/CD3+显著性增加(P<0.01),CD3+、CD19+/CD3-无明显改变(P>0.05)。结论老年铜绿假单胞菌性肺炎患者有淋巴细胞功能紊乱及免疫功能障碍。
OBJECTIVE To study the cell-mediated immune function among older inpatients with Pseudomonas aeruginosa pneumonia.METHODS T-cell subsets and expression of membrane molecule on activated T-cell in peripheral blood were measured in 35 cases with P.aeruginosa pneumonia by using immunofluorescence and flow cytometry,and compared with those of control healthy older people.RESULTS The expressions of CD4^＋ /CD3^＋ and CD25^＋ /CD3^＋ in P.aeruginosa pneumonia patients were lower than in control group（P〈0.05）.The expression of CD4^＋/CD8^＋,HLA-DR^＋ /CD3^＋ and CD16^＋56^＋ /CD3^-in P.aeruginosa pneumonia patients was singnificant lower than control group（P〈0.01）.But there was no singnificant difference in CD3^＋,CD19^＋/CD3^-between the two groups（P〉0.05）.CONCLUSIONS There are disfunctions of lymphocgte and immunity among P.aeruginosa pneumonia patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2008年第4期467-469,共3页
Chinese Journal of Nosocomiology
