摘要
目的:研究超声聚能刀(HIFU)治疗前列腺癌对血清前列腺特异性膜抗原(PSMA)水平变化及特异性激活细胞毒性T淋巴细胞活性的影响。方法:8例确诊前列腺癌患者,ELISA法检测HIFU治疗前后血清PSMA,混合淋巴细胞反应检测特异性细胞毒性T淋巴细胞的增殖。结果:HIFU治疗后,血清PSMA升高,并可显著刺激特异性T淋巴细胞增殖,与对照组比较具有显著性差异(P<0.01)。结论:HIFU治疗可有效激活机体PSMA特异性的T细胞。
Objective investigate the effects of treatment of prostate cancer by high intensity focused ultrasourd（HIFU） on serum prostate specific membrane antigen（PSMA） and activation of cytotoxic T lymphocytes Methods：8 cases of prostate cancer were treated by HIFU. Before and after the treatment, the levels of their serum PSMA were detected by ELISA and the proliferation of specific cytotoxic T lymphocytes was examined by mixed lymphocyte reaction method. Results： After treated by HIFU, the level of PSMA of the patients increased and the proliferation of cytotoxic T lymphocytes was strongly activated. Compared with the control group, the changes of PSMA and proliferation of cytotoxic T lymphocytes were very significan different（P〈0. 01）, Conclusions： HIFU could activate effectively the PSMA specific T lymphocyte.
出处
《西南国防医药》
CAS
2008年第2期172-173,共2页
Medical Journal of National Defending Forces in Southwest China
基金
南京军区医药卫生科研项目(06MA71)
