4Cao R, Brakenhielm E, Wahlestedt C, et al. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF [J]. Proc Natl Acad Sci USA, 2001,98 (11) : 6390-6395.
6Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK,JNK,and p38 protein kinases [J]. Science, 2002,298(5600) : 1911-1912.
7Yoo J, Park SY, Robinson BA, et al. Ras gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas [J]. Arch Pathol Lab Med 2002,126(9) :1096- 1100.
8Pai R,Lin C, Tran T, et al. Leptin activates STAT and ERK2 pathways and induces gastric cancer cell proliferation [J]. Biochem Biophys Res Commun, 2005 , 331 (4) : 984-992.
二级参考文献16
1Calle EE,Rodriguez C,Walker-Thurmond K,et al.Overweight,obesity,and mortality from cancer in a prospectively studied cohort of US adults[J].N Engl J Med,2003,348 (17):1625-1638.
2Attoub S,Noe V,Pirola L,et al.Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-,rho-,and rac-dependent signaling pathways[J].FASEB J,2000,14(14):2329-2338.
3Hardwick JC,van den Brink GR,Offerhaus GJ,et al.Leptin is a growth factorfor colonic epithelial cells[J].Gastroenterology,2001,121(1):79-84.
4Mix H,Widjaja A,Jandl O,et al.Expression of leptin and leptin receptor isoforms in the human stomach[J].Gut,2000,47(4):481-486.
5Cao R,Brakenhielm E,Wahlestedt C,et al.Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF[J].Proc Natl Acad Sci USA,2001,98(11):6390-6395.
6Yamagishi S,Inagaki Y,Amano S,et al.Up-regulation of vascular endothelial growth factor and down-regulation of pigment epithelium-derived factor messenger ribonucleic acid levels in leptin-exposed cultured retinal pericytes[J ].Int J Tissue React,2002,24(4):137-142.
7Maeda K,Chung YS,Ogawa Y,et al.Prognostic value of vascular endothelial growth factor expression in gastric carcinoma[J].Cancer,1996,77(5):858-863.
8Schneider R,Bornstein SR,Chrousos GP,et al.Leptin mediates a proliferative response in human gastric mucosa cells with functional receptor[J].Horm Metab Res,2001,33(1):1-6.
9Bouloumie A,Drexler HC,Lafontan M,et al.Leptin,the product of Ob gene,promotes angiogenesis[J].Circ Res,1998,83(10):1059-1066.
10Azumaa T,Sutoa H,Itoa Y,et al.Gastric leptin and Helicobacter pylori infection[J].Gut,2001,49(3):324-329.
4Chen YC, Shen SC, Chow JM, et al. Flavone inhibition of tumor growth via apoptosis in vitro and in vivo [ J ]. Int J Onool, 2004, 25 (3) : 661 -670.
5Paik SS, Jang SM, Jang KS, et al. Leptin expression correlates with favorable clinicopat hologic phenotype and better prognosis in colorec- tal adenocarcinoma[J]. Ann Surg Oncol, 2009, 16(2) : 297 -303.