转化生长因子β1诱导肾小管上皮细胞趋化因子的表达被引量：3

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摘要近年来研究表明，肾间质损害的主要参与者炎性细胞在趋化因子招募下开始浸润至肾间质并进一步活化，因此趋化因子的表达与肾脏疾病，尤其是与肾小管间质病变的关系受到众多研究者的关注。本研究将观察人近端肾小管上皮细胞（HK-2）在转化生长因子β1（TGF-β1）作用下单核细胞趋化蛋白1（MCP-1）、白介素8（IL-8）和正常T细胞活化后表达和分泌调节蛋白（RANTES）的分泌变化，以探讨TGF-β1对趋化因子表达的调节作用。

作者章慧娣王伟铭靳远萌朱冰冰陈楠

机构地区上海交通大学医学院附属瑞金医院肾脏科

出处《中华肾脏病杂志》 CAS CSCD 北大核心 2008年第2期138-139,共2页 Chinese Journal of Nephrology

基金国家自然科学基金（30270613）上海市卫生局重点学科基金（05Ⅲ001）上海市重点学科（1U201）上海市卫生局重点课题（2003ZD002）

关键词上皮细胞趋化因子转化生长因子Β1 肾小管间质病变人近端肾小管上皮细胞单核细胞趋化蛋白 TGF-β1 肾间质损害 T细胞活化

分类号 R692.6 [医药卫生—泌尿科学]

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参考文献6

1Zoja C, Donadelli R, Colleoni S, et al. Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Kidney Int, 1998,53: 1608-1615.
2Tesch GH, Schwarting A, Kinoshita K, et al. Monocyte chemoattractant protein- 1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J Clin Invest, 1999,103:73-80.
3Gerritsma JS, Hiemstra PS, Gerritsen AF, et al. Regulation and production of IL-8 by human proximal tubular epithelial cells in vitro. Clin Exp Immunol, 1996,103:289-294.
4Gerritsma JS, Kooten C, Gerritsen AF, et al. Transforming growth factor-beta 1 regulates chemokine and complement production by human proximal tubular epithelial cells. Kidney Int, 1998,53:609-616.
5Qi w, Chen X, Polhill TS, et al. TGF-betal induces IL-8 and MCP- 1 through a connective tissue growth factorindependent pathway. Am J Physiol Renal Physiol, 2006, 290: F703 - F709.
6陈楠,赵青,王伟铭,卢健.转化生长因子-β刺激人近端肾小管上皮细胞结缔组织生长因子的表达[J].肾脏病与透析肾移植杂志,2005,14(2):117-121. 被引量：10

二级参考文献11

1Border WA, Noble NA. TGF-beta in kidney fibrosis: A target for gene therapy. Kidney Int, 1997, 51: 1388-1397.
2Riser BL, Denichilo M, Cortes P, et al. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol, 2000, 11: 25-38.
3Heusinger RJ, Eberlein M, Wahab NA, et al. Expression of connective tissue growth factor in human renal fibroblasts: regulatory roles of RhoA and camp.J Am Soc Nephrol, 2001, 12: 1853-1861.
4Gupta S, Clarkson MR, Duggan J. Connective tissue growth factor: potential role in glomerulosclerosis and tubulointerstitial fibrosis. Kidney Int, 2000, 58: 1389-1399.
5Ito Y, Aten J, Bende RJ, et al. Expression of connective tissue growth factor in human renal fibrosis. Kidney Int, 1998, 53: 853-861.
6Zhang SY, Suzuki D, Umezono T, et al. Expression of connective tissue growth factor mRNA in human IgA nephropathy. Clin Exp Nephrol, 2001, 5: 33-39.
7Abbate M, Zoja C, Rottoli D, et al. Proximal tubular cells promote fibrogenesis by TGF-β1-mediated induction of peritubular myofibroblasts. Kidney Int, 2002, 62: 2066-2077.
8Fine LG, Norman JT, Ong A.Cell-cell cross-talk in the pathogenesis of renal interstitial fibrosis. Kidney Int, 1995,47 ( Suppl 49): S48-S50.
9Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ,1996, 7: 469-480.
10黄海长,李惊子,王海燕.结缔组织生长因子诱导肾成纤维细胞转为成肌纤维细胞[J].科学通报,2002,47(1):37-40. 被引量：65