摘要
目的测定2％利多卡因联合0．75％罗哌卡因10ml使患者坐骨神经阻滞起效时间≤15min的2％利多卡因半数有效量（EDS0）。方法2％利多卡因按不同剂量等比地分7个等级，以腓肠神经外侧皮支、腓浅神经、胫神经跟内侧支感觉阻滞起效时间均≤15min为观察指标，用序贯法分别测定与0．75％罗哌卡因10ml合用后引出趾背曲（腓总神经特征）和引出趾跖曲（胫神经特征）时2％利多卡因的ED50。结果2％利多卡因联合罗哌卡因在引出趾背曲和趾跖曲的患者中使腓肠神经外侧皮支、腓浅神经、胫神经跟内侧支感觉阻滞起效时间均≤15min的2％利多卡因ED50分别为6．19ml和6．88ml。结论2％利多卡因联合罗哌卡因在引出趾背曲和趾跖曲的患者中使腓肠神经外侧皮支，腓浅神经，胫神经跟内侧支感觉阻滞起效时间均≤15min的2％利多卡因ED50分别为6．19和6．88ml。坐骨神经阻滞时，引出趾背曲的患者与引出趾跖曲的患者注药量相似。
Objective To determine the median effective dose （ED50） of 2% lidocaine to control the onset time of sciatic nerve blockade within 15 min by using 2% lidocaine and 0.75% ropivacaine 10 ml. Methods Fifty patients underwent sciatic nerve blockade and lumbar plexus blockade for operations of unilateral lower extremities. 2% lidocaine was allocated into 7 ranks in geometric proportion between 4.2 ml and 12.5 ml. The observed index was the blockade onset time less than 15 rain of the lateral cutaneous branch of sural nerve, fibular nerve, and rami calcanei mediales nervi tibialis. The EDs0 of 2% lidocaine was determined respectively in the patients in which dorsiflexion or plantarflexion was elicited by in up-and- down sequential method. Results Combined with ropvacaine, the values of ED50 of 2% lidocaine in the patients in which dorsiflexion and plantarflexion were elicited by up-and-down sequential method were 6.88 ml and 6.19 ml respectively when the onset time of blockade of sciatic nerve was within the range of 15 min. Conclusion The dosage to elicit plantarflexion is similar to the dosage to elicit dorsiflexion in sciatic nerve blockade.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2008年第9期594-596,共3页
National Medical Journal of China
基金
浙江省科技厅资助项目（2005C33015）
关键词
利多卡因
坐骨神经
麻醉
半数有效量
Lidocaine
Sciatic nerve
Anesthesia
Median effective dose
