摘要
对卡托普利缓释片进行了ｐＨ－时间－溶出度的三维溶出试验，研究表明：ｐＨ在１．０～７．４范围内对药物的溶出度影响不大，该片在２、６和１２ｈ的溶出率可控制在２０％～４５％，４５％～７０％和７５％以上；另将体外溶出率与体内吸收百分率进行相关性分析，相关系数ｒ＝０．９９８９，说明该药的体内外相关性较好。
The three dimension (pH time solubility) soluble test of slow released captopril was performed. The results indicated that the effects of pH (range from 1.0 to 7.4) on the solubility of drug was little and that the soluble rate could be controlled by 20%￣45%,45%￣70% and 75% at 2,6 and 12 hours,respectively. In addition, the correlation between the soluble rate in vitro and the percentage of absorption in vivo of this drug was analyzed (r=0.9989) and the correlationship was quite well.
出处
《广东药学院学报》
CAS
1997年第2期71-74,共4页
Academic Journal of Guangdong College of Pharmacy
关键词
卡托普利
缓释片
溶出度
体内外相关性
降压药
captopril
slow released tablet
3 D Solubility
the correlation between in vitro and in vivo
