摘要
目的:研究三种不同形态替莫唑胺(TM)胶囊[TM(A)、TM(B)、TM(C)]的溶出度及其在家兔体内的生物利用度。方法:将三种TM分别制成胶囊剂,测定其在0.1 mol/L盐酸中的溶出度。以家兔为实验动物,分别测定三种TM胶囊的绝对生物利用度,评价其生物等效性。结果:TM(C)胶囊溶出最快,TM(A)次之,TM(B)最慢;TM(A)与TM(B)的生物利用度不存在显著性差异(P>0.05),而TM(C)的生物利用度明显低于TM(A)和TM(B)(P<0.01)。结论:TM(A)与TM(B)在家兔体内具有生物等效性,而TM(C)为低效的一种形态。
Objective： To study three morphological temozolomide （TM） capsules＇ dissolutions and absolute bioavailabilities in rabbits. Methods： The dissolution of differently morphological TM capsules was determined by UV spectrophotometry. The pharmacokinetics and bioavailability of three morphologies （A, B and C） in rabbits were studied. Results： The results from Weibull＇s analysis showed that the dissolutions of TM capsules were very different, the dissolution rate of TM（C） was the fastest and that of TM（B） was the slowest; The bioavailability of TM（A） and TM（B） were bioequivalent （P〉0.05）, but that of TM（C） was obvious lower than the others （P 〈0.01）. Conclusion： TM capsule A and B are bioequivalent and TM（C） is lower in the bioavailability in rabbits.
出处
《山东大学学报（医学版）》
CAS
北大核心
2006年第9期942-945,共4页
Journal of Shandong University:Health Sciences
关键词
替莫唑胺
多晶型
胶囊
生物利用度
Temozolomide
Polymorphism
Capsule
Bioavailability
