摘要
目的:评价齐拉西酮治疗精神分裂症的疗效和不良反应。方法:80例精神分裂症患者,按入院顺序随机分为齐拉西酮组(40例)和利培酮组(40例)进行治疗6周观察。采用阳性与阴性症状量表(PANSS)评定疗效,用治疗中出现的症状量表(TESS)和锥体外系反应量表(RSESE)评定不良反应。结果:2药疗效相当。齐拉西酮组的锥体外系反应明显较少。结论:齐拉西酮为一种安全有效和耐受性较好的抗精神病药。
Objective：To evaluate the efficacy and side effects of ziprasidone in treatment of schizophrenia. Method： According to hospitalization sequence, 80 patients with schizophrenia were randomly divided into two groups, ziprasidone group （ n = 40） and resperidone group （ n = 40） were treated for 6 weeks. The efficacy and side effects were evaluated by positive and negative symptoms scale （PANSS） and treatment emergent symptoms scale （TESS） and rating scale for extrapyrmnidel side effects （RSESE） respectively. Results： The efficacy was similar for ziprasidone and risperidone. Extraprmidal side effects in patients of ziprasidone group were significantly fewer. Conclusion： Ziprasidone was a antipsyehotic with better efficacy and tolerance and less side effects.
出处
《临床精神医学杂志》
2008年第1期35-37,共3页
Journal of Clinical Psychiatry
