摘要
目的探讨中国北方汉族人群肿瘤坏死因子（TNF—α）基因多态性与慢性阻塞性肺疾病（COPD）之间的关系。方法采用病例对照研究和聚合酶链反应-限制性片段长度多态性技术检测COPD患者TNF—α等位基因变异分布。结果COPD组和健康对照组TNF-α突变型基因频率分别为18．06％和2．14％，2组比较差异有统计学意义（P〈0．05）；等位基因频率分别为36％和18％，2组比较差异有统计学意义（P〈0．01）。结论TNF-α基因多态性与COPD发生相关联。
Objective To investigate the relations betireen the genetic polymorphism of human TNF-α and susceptibility of chronic obstructive pulmonary disease （ COPD }. Methods Case-control study was used to compare the frequent distribution of TNF-α genetypes with a polymerase chain reaction-fragment polymorphism （ PCR- RELP}. Results The heterogenesis gene frequency of TNF-α in COPD group and control group were 18.06% and 2.14% with significant difference （ P 〈 0.05 ）. The allele frequency of TNF-α in COPD group and control group were 36% and 18% with significant difference （ P 〈 0.01 ）. Conclusion Genetic polymorphism of TNF-α is related to the development of COPD.
出处
《中国综合临床》
北大核心
2008年第2期129-130,共2页
Clinical Medicine of China
基金
河北省科技计划指导项目（062761939）
关键词
慢性阻塞性肺疾病
肿瘤坏死因子-Α
基因多态性
Chronic obstructive pulmonary disease
Tumor necrosis factor-α
Genetic polymorphism
