摘要
目的:研究TNF-α-308位点多态性与COPD发病风险的关联程度。方法:计算机检索CNKI、Pub Med、Embase、Wan Fang、CBM、维普智立方文献数据库,检索国内外有关TNF-α-308多态性与COPD易感性之间的病例(对照研究),从建库查找到2017年8月14日,共3名评价者依照纳入以及排除标准甄选出文献,对文献进行了整理和评价,用Rev Man 5.2应用软件对整理的文献做了Meta分析。结果:最后共纳入病例(对照研究)18篇,有病例组患者1697例、对照组患者1671例;在研究人群种族的基础上,对中国的汉族人群进行了亚组分析,Meta分析结果表明:TNF-α-308与COPD易感性有关联(RR=2.25,95%CI=[1.84,2.76],P[0.00001)。结论:TNF-α-308基因的多态性与COPD的易感性可能有关联。
Objective To study the association between polymorphism of TNF-α-308 locus and risk of COPD. Methods CNKI,Pub Meded,Embase,Wan fang,CBM,Weipuchi cubic literature database were searched by computer. A case-control study on the relationship between TNF-α-308 polymorphism and susceptibility to COPD was conducted at home and abroad. The literature was reviewed and evaluated with Rev Man 5. 2. The software was used to do Meta analysis of the collected literature. Results A total of 18 case-control studies were conducted. There were 1697 patients in the case group and 1671 patients in the control group. The results of meta analysis in Chinese Han population showed that TNF-α-308 was associated with susceptibility to COPD（ RR = 2. 25,CI = [1. 84,0. 76],P [0. 00001].Conclusion The polymorphism of TNF-α-308 gene may be associated with susceptibility to COPD.
作者
谢卓君
辛甜青
谢文佳
张毅
XIE Zhuojun;XIN Tianqing;XIE Wenjia;ZHANG Yi(Gansu college of TCM,Lanzhou 730000,China)
出处
《中国民族民间医药》
2018年第15期59-62,65,共5页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
国家自然基金(81460709)
甘肃省科技支甘计划(NO:1011JKCA175)
2017学生科技学术创新基金项目(2017)
