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脆性组氨酸三联体与caspase-3在上皮性卵巢癌中的表达及意义 被引量：5

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摘要 目的探讨脆性组氨酸三联体(F HIT)与caspase一3在不同的卵巢组织中的表达及其临床意义。方法正常卵巢14例,均为子宫肌瘤行子宫全切加一侧卵巢切除术的卵巢组织;良性囊腺瘤15例;交界性囊腺瘤15例;上皮性卵巢癌38例,上皮性卵巢癌标本未经任何抗癌治疗。检测脆性组氨酸三联体与caspase-3。结果除FHIT在上皮性卵巢癌组织中的缺表达率分别显著高于正常卵巢、良性囊腺瘤和交界性囊腺瘤等三种卵巢组织外,在正常卵巢、良性囊腺瘤、交界性囊腺瘤卵巢组织中差异无显著性,在上皮性卵巢癌组织中的比较差异无显著性;caspase-3在正常卵巢、良性囊腺瘤、交界性囊腺瘤等三种卵巢组织中的表达率差异有显著性,在正常卵巢、良性囊腺瘤、交界性囊腺瘤卵巢组织中差异无显著性。结论病理分级越低和临床分期越高则FHIT的表达率越低,FHIT的表达与年龄和月经无关。提示FHIT的缺表达可能与卵巢癌细胞的恶性程度、侵袭力和转移能力,以及卵巢癌的发展及预后有关,可能成为卵巢癌的恶性程度和预后的预测性指标。caspase-3在未化疗的上皮性卵巢癌中的表达率显著低于正常卵巢、良性囊腺瘤和交界性囊腺瘤;caspase-3还与临床分期有关,临床分期越晚则表达率越低。
作者 徐敏娟 张春年 王建中
机构地区 江西省赣州市人民医院妇产科
出处 《中国医刊》 CAS 2012年第12期65-67,共3页 Chinese Journal of Medicine
关键词 脆性组氨酸三联体 CASPASE-3 上皮性卵巢癌 表达
分类号 R737.31 [医药卫生—肿瘤]
  • 相关文献

参考文献10

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共引文献12

同被引文献48

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引证文献5

二级引证文献38

中国医刊
2012年 第12期

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