摘要
[目的]探讨临床肠杆菌科细菌产超广谱β-内酰胺酶状况,为临床用药提供参考依据。[方法]采用纸片扩散初筛法与确证试验检测临床分离肠杆菌科细菌产超广谱β-内酰胺酶菌株。[结果]743株肠杆菌科细菌检出产超广谱β-内酰胺酶菌341株(45.9%),其中176株(52.5%)来源于痰标本;产超广谱β-内酰胺酶菌类别达13种;大肠埃希菌、克雷伯菌和阴沟肠杆菌在ESBLs阳性菌株中的构成比依次为42.8%、41.6%和6.5%,产酶率则分别为48.0%、56.3%和37.9%。[结论]肠杆菌科细菌产超广谱β-内酰胺酶检出率高、产酶菌种多,临床实验室应加强检测,指导临床合理使用抗菌药物。
[Objective] To investigate the production and distribution of extended spcctrum β-lactamase （ESBLs） in Enterobactericaeae, and to provide references for the clinical application of drugs. [ Methods] ESBLs were detected by disc diffusion confirmatory test. [Results] 743 strains of Enterobacteriaceae were indeutified and amoug them 341 ESBLs straius were isolated, 176 ESBLs strains were isolated from sputum specimens; 13 kinds of Enterobacteriaceae produced ESBLs strains. The constituent ratio of E.coli, Klebsiella spp and E.cloacae in ESBLs positive strains were 42.8%, 41.6% and 6.5% respectively, the ESBLs isolating ratea of which were 48.0%, 56.3% and 37.9% respectively. [Conclusion] The detection rates of ESBLs in enterobaeteriaceae are high, and the categories of producing ESBLs in Enterobacteriaceae are many. It is necessary for clinical laboratory to carry out routine detection on ESBLs in clinical isolates of Enterobacteriaceae.
出处
《现代预防医学》
CAS
北大核心
2008年第3期597-598,共2页
Modern Preventive Medicine
